Pharmacological action Humalog Mix 75/25
DNA-recombinant human insulin analogue. It is a mixture of insulin lispro (25%) – high-speed preparation of insulin and insulin lispro protaminovoy suspension (NPL) (75%) – a drug intermediate-acting insulin.
The main effect of the drug is regulation of glucose metabolism. In addition, it has an anabolic effect. In muscle and other tissues (except brain) insulin accelerates the intracellular transport of glucose and amino acids accelerates anabolism of proteins. Promotes conversion of glucose into glycogen in the liver, inhibits gluconeogenesis and stimulates the conversion of excess glucose into fat.
Insulin lispro insulin ekvimolyaren man. It is characterized by a more rapid onset of action, the earlier the onset of peak action and a shorter period of hypoglycemic activity compared with normal human insulin.
Results of studies in healthy volunteers with the fixation of glucose showed that the absorption profile of the NPL and is similar to that of the suspension isophane human insulin (NPH).
Pharmacokinetics Humalog Mix 75/25
Earlier onset of drug action, about 15 minutes after injection, associated with a higher rate of its absorption. This allows you to enter the drug immediately before a meal (15 min) in contrast to conventional human insulin, which is injected 30 minutes before eating. At the rate of absorption of insulin lispro and, consequently, the beginning of his actions may affect the choice of injections.
Statement Humalog Mix 75/25
- Treatment of diabetes in the presence of indications for insulin therapy.
Dosage and administration Humalog Mix 75/25
The dose is determined individually depending on the level of glycemia. Rapid onset of action of insulin lispro allows you to enter it for 15 minutes before a meal.
Humalog Mix 75/25 is introduced only n / k. The drug should not be given / in.
N / a is introduced into the shoulders, hips, buttocks or abdomen. Injection sites should be rotated so that the introduction in the same place made no more than about 1 times / month. When s / c infusion Humalog Mix 75/25 should be careful to avoid getting the drug into a blood vessel. Patients should be taught the proper use of insulin injection devices.
When using the bottle before applying to be a few times or turn the bottle until perekatat mixing insulin. After mixing, the insulin should look uniformly cloudy or like milk. Otherwise, repeat the above manipulation, while the contents are not mixed. For insulin use insulin syringe with markings indicating that it is designed for use with insulin concentration of 100 IU / ml.
If you use cartridges, which should be 10 times perekatat cartridge between your palms. Then, holding the cartridge in the cork should slowly turn it over 10 times at 180 °, so that the glass ball with each rollover moved the entire length of the cartridge. After mixing, the insulin should look uniformly cloudy or like milk. Otherwise, repeat the above manipulation, while the contents are not mixed. Recommendations for installing the cartridge into the device for insulin delivery and adherence to it before the introduction of insulin needles should be read in the instructions to the device manufacturer for insulin.
You can not use insulin if a white precipitate remains on the bottom of the vial after mixing, if it has, after mixing flakes, if the bottom or the walls of the bottle stuck solid white particles, creating the effect of frost.
In patients with renal and / or liver failure circulating levels of insulin increased, therefore, insulin requirements may be reduced. This requires careful control of glycemia and correction doses. More rapid onset and shorter duration of action of insulin lispro compared with regular human insulin in patients with renal and hepatic failure persists.
Side effect Humalog Mix 75/25
Adverse effects associated with the main action of the drug: hypoglycemia.
Allergic reactions: local allergic reaction – redness, swelling or itching at the injection site (usually disappear over a period of several days to several weeks in some cases, these reactions can be caused by factors not related to insulin, such as irritation of the skin cleaning agent or improper injection) systemic allergic reactions (occur rarely, but are more serious) – generalized itching, difficulty breathing, shortness of breath, decreased blood pressure, increased heart rate, increased sweating. Severe cases of systemic allergic reactions may be life-threatening.
On the part of the vision: transient disturbances of refraction (usually in patients who have not received insulin).
Other: lipodystrophy.
Contraindications Humalog Mix 75/25
- Hypoglycemia;
- Hypersensitivity to insulin lispro or to any of the ingredients of the drug.
Pregnancy and breast feeding Humalog Mix 75/25
Clinical trials on the drug Humalog Mix 75/25, with pregnancy have been conducted. In the case of planned pregnancy or the ensuing diabetic patients is recommended to inform your doctor.
It is unknown whether insulin lispro is allocated or insulin lispro protaminovaya suspension in significant amounts in breast milk. Patients with diabetes during lactation may require adjustment of insulin dose and diet.
Application of human liver Humalog Mix 75/25
In patients with hepatic impairment increased level of circulating insulin, so insulin requirements may be reduced. This requires careful control of glycemia and correction doses. More rapid onset and shorter duration of action of insulin lispro compared with regular human insulin in patients with liver failure remains.
Use in renal impairment Humalog Mix 75/25
In patients with renal insufficiency increased the level of circulating insulin, so insulin requirements may be reduced. This requires careful control of glycemia and correction doses. More rapid onset and shorter duration of action of insulin lispro compared with regular human insulin in patients with renal insufficiency persists.
Cautions
When assigning patients with diabetes mellitus Humalog Mix 75/25 may need to change the dose, which was used in the previous scheme insulin. Any change of insulin should be done cautiously and only under medical supervision. Changes in the activity of insulin, but its type (eg regular, NPH), a specific accessory (porcine, human insulin analogue insulin human) or method of manufacture (recombinant DNA insulin or insulin of animal origin) may lead to the correct dose.
Hypoglycemia is the most common side effects that occur with the introduction of insulin, including Humalog Mix 75/25 . Severe hypoglycemia can lead to unconsciousness and, in extreme cases, death. Under certain conditions, such as long duration or with intensive control of diabetes, early signs of hypoglycemia may differ or be less pronounced.
During various diseases or emotionally straining insulin requirements may increase.
In the presence of renal or hepatic impairment, insulin requirements may be reduced.
Correction doses of insulin may also require an increase in physical activity or when the usual diet.
If necessary, take other drugs along with drug Humalog Mix 75/25 the patient should consult a physician.
Use in Pediatrics
Safety and efficacy of Humalog Mix 75/25 in children and adolescents under the age of 18 years has not been established.
Effects on ability to drive and control mechanisms
Proper administration of adequate doses of insulin has no effect on ability to drive and control mechanisms.
The ability of the patient to the concentration and quick reactions may be reduced as a result of hypoglycemia. This may create a risk in situations where this ability is particularly important (for example, when performing work that requires concentration and quickness of psychomotor reactions).
Overdose Humalog Mix 75/25
Symptoms: hypoglycemia, accompanied by the following symptoms: fatigue, increased sweating, tachycardia, pale skin, headache, tremors, vomiting, confusion.
Treatment: mild state of hypoglycemia usually cropped ingestion of glucose (dextrose). May require adjustment of insulin dose, diet or physical activity. Severe hypoglycemia condition, accompanied by coma, convulsions or neurological disorders, cropped / m or s / c infusion of glucagon or / in the introduction of a concentrated solution of glucose (dextrose). After regaining consciousness the patient must give food rich in carbohydrates, in order to avoid a recurrence of hypoglycemia.
Drug Interactions Humalog Mix 75/25
Hypoglycemic effect of reducing Humalog Mix 75/25 oral contraceptives, corticosteroids, thyroid hormone drugs, thiazide diuretics, diazoxide, tricyclic antidepressants.
Hypoglycemic effect Humalog Mix 75/25 reinforce oral hypoglycemic agents, salicylates (eg aspirin), sulfonamides, MAO inhibitors, beta-blockers, ethanol and etanolsoderzhaschie drugs.
Beta-blockers, clonidine, reserpine, may mask the symptoms of hypoglycemia.
